操纵、伪造实验数据长达12年之久(从2002年到2014年),俄亥俄州立大学教授Samson Jacob仍然熬到了名誉教授的荣休身份。而学校的一项学术不端调查,却让他名誉扫地。2021年5月,Samson Jacob被取消退休职位。俄亥俄州立大学表示Samson Jacob在研究中存在不当行为,并且他的实验室存在“放任数据操纵”的风气。校方表示“他已与大学没有任何关系”。
俄亥俄州立大学调查发现有20篇研究论文存在学术不端。截至到2023年12月17日,Samson Jacob被撤回17篇文章(在2023年12月15日被撤回4篇Cancer Research 文章)。
2021年2月,经过俄亥俄州立大学(Ohio State University)调查委员会长达5年、对67项指控的调查,公布了一份长达209页的调查报告。报告显示,在2002-2014年,Samson Jacob团队发表的论文中明显存在大量被操纵的图像,委员会确信“Samson Jacob实验室中存在一种允许的操纵数据文化,尤其是对照组数据,这不是由于疏忽造成的错误。” 调查发现有20篇研究论文存在学术不端。此前的2018年,雅各布等已被撤稿9篇,更正1篇。委员会要求,立即撤回其余的10篇,并建议对其进行制裁。
目前,委员会的建议正在实施中。2021年5月,Samson Jacob被取消退休职位。俄亥俄州立大学表示Samson Jacob在研究中存在不当行为,并且他的实验室存在“放任数据操纵”的风气。校方表示“他已与大学没有任何关系”。 委员会提出了3点建议:一是禁止雅各布进行所有研究、带研究生等其他研究者,并禁止在3年内提交联邦资助申请;二是撤销他的退休职位和杰出教师身份;三是要求自报告之日起的3年内,取消他的PI身份。[1]PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells,Journal of Biological Chemistry ;
[2]Identification of T-cadherin as a novel target of DNA methyltransferase 3B and its role in the suppression of nerve growth factor-mediated neurite outgrowth in PC12 cells,Journal of Biological Chemistry;[3]Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription,Journal of Biological Chemistry;[4]Treatment of PC12 cells with nerve growth factor induces proteasomal degradation of T-cadherin that requires tyrosine phosphorylation of its cadherin domain,Journal of Biological Chemistry;[5]Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma,Journal of Biological Chemistry;[6]Identification of a novel cyclic AMP-response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene,Journal of Biological Chemistry;[7]Mitochondrial transcription factor A and its downstream targets are up-regulated in a rat hepatoma,Journal of Biological Chemistry;[8]Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1,Journal of Biological Chemistry;[9]Anti-microRNA-222 (anti-miR-222) and -181B suppress growth of tamoxifen-resistant xenografts in mouse by targeting TIMP3 protein and modulating mitogenic signal,Journal of Biological Chemistry;[10]HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors,PLOS ONE ;
[11]Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer,PNAS ;[12]DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2,Molecular and Cellular Biology ;[13]5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal,Molecular and Cellular Biology ;[14]Methylation Mediated Silencing of MicroRNA-1 Gene and Its Role in Hepatocellular Carcinogenesis,Cancer Res ;[15]A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation,Cancer Res ;[16]Loss of Metallothionein Predisposes Mice to Diethylnitrosamine-Induced Hepatocarcinogenesis by Activating NF-κB Target Genes,Cancer Res ;
[17]Physical and Functional Interaction of DNA Methyltransferase 3A with Mbd3 and Brg1 in Mouse Lymphosarcoma Cells,Cancer Res ;
https://retractionwatch.com/2022/07/25/exclusive-osu-investigation-finds-dishonesty-and-permissive-culture-of-data-manipulation-in-cancer-research-lab/